Cannabis Science

Mixing Shrooms and Weed: Is It Safe?

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Is mixing shrooms and weed safe? Here’s what we know. 

Photo: Pexels

Shrooms vs Weed: Similarities and Differences 

Even though shrooms and weed are two completely different plants, they are similar in some ways.

The most significant similarity is that they both cause certain effects such as euphoria, anxiety, an increase in your heart rate, and dilated pupils.  In addition, they are both being researched for the effects of mental illnesses such as depression. 

As a matter of fact, microdosing weed or shrooms may help relieve certain ailments such as pain according to recent studies but more search is needed. 

However, there are some effects more common with shrooms than weed, even though they share pretty similar effects.

For example, magic mushrooms can cause frightening hallucinations, unusual body sensations, and spirit awakenings according to Medical News Today. 

Another difference between both is how they cause their effects. 

Medical News Today says shrooms activate the serotonin receptors, mostly in the prefrontal cortex. This explains the change in perception, mood, and cognition when on shrooms. 

On the other hand, the cannabinoids from weed target different receptors. A 2021 study says, “THC and CBD bind with cannabinoid receptors (CB1 and CB2), which are present in the brain and many organs.”

The endocannabinoid system influences neuronal synaptic communication and affects biological functions such as eating and metabolism. This explains why hitting a bong makes you hungry

In terms of how long either takes to kick in, they similarly vary in time due to many factors. The time it takes for either to kick in depends on its potency, how much of it you use, the method of use, and the individual themselves. For example, your metabolism and tolerance will have an effect on your experience with them. 

Can You Smoke Shrooms With Weed?

We couldn’t find any research that examined the effects of using both together.

However, we don’t recommend smoking shrooms as it can result in abdominal cramps, nausea, and other uncomfortable side effects. In addition, you may expose the lungs to mold spores.

Smoking shrooms also may dull your trip. Adding heat to shrooms can destroy the psilocybin which is the main compound that produces euphoria. That’s why most people eat shrooms, instead of smoking them.

Can You Smoke Weed on Shrooms? 

You can technically smoke weed with shrooms however, it’s not for everyone. 

For example, mixing weed and shrooms is not recommended for people new to either.

It’s not recommended for newbies because of the potential intensity of the high or psychedelic trip. 

Healthline says, “combining mushrooms with THC-rich strains can increase the intensity of the trip. It may cause more interesting and intense visual and auditory hallucinations, as well as more intriguing thought patterns.” 

They caution against this combo because the intensity may be too much and unpleasant. 

Reddit users also shared similar sentiments. 

One person cautioned newbies from combining the two expressing that, “for somebody who’s an amateur I would never recommend adding anything that can add to stress or a panic attack if anything.”

Another said it was unpleasant and cautioned people. They said, “I’d refrain, just from my own experience, weed has made my trips worse sometimes, especially if I’m not coming down.”

Finally, one Reddit user said, “Mushrooms can get emotionally overwhelming on their own and mixing it with weed is a recipe for disaster if doing shrooms for the first time. Weed is nice to combine with psychedelics but you shouldn’t do so until you know how YOUR BODY reacts to them.”

Newbies aren’t the only ones at risk for unpleasant effects. Anyone can have a bad experience with weed or shrooms and so it’s possible when both are mixed. 

Positive Experiences Combining Shrooms and Weed 

Mixing shrooms and weed can be a positive experience.

Healthline says that based on online anecdotal reports, a more CBD-rich strain combined with shrooms could reduce nausea and anxiety common with shrooms. 

In addition, other Reddit users enjoyed mixing shrooms and weed.

One Reddit user said, “weed saved me from a bad trip, my friends all said not to smoke but it was the only thing that stopped me from spiraling out and let me enjoy the ride!”

In another Reddit thread, one user said, “For me, it increased the euphoria and visuals by 10 fold while muting some anxiety that I had. It’s pretty great.”

While another chimed in with, “You’ll feel a connection to cannabis that you’ve never felt before.”


So, shrooms and weed, is it safe? We don’t know any serious risks about combining the two. There is also little to no research that speaks about their combined effects. We look forward to future research.


About Trevann

Trevann is Stoner Rotation’s Jamaica-based lead writer for the Science section of our cannabis blog. She graduated with honors receiving her Bachelor of Science degree in Molecular Biology from the University of West Indies, Mona. For the last three years, she has covered some of the biggest questions around cannabis and health underpinned with research from supporting studies, medical journals and scholarly articles. Got something on your mind? You can reach her at [email protected].